形觉剥夺性近视/弱视对小鼠高血糖视网膜微血管病变影响的形态学观察

摘要

Objective To observe whether form-deprivation myopia/amblyopia could protect retinal microvascular system and postpone the development of diabetic retinopathy. Methods The form-deprivation myopia/amblyopia was established combined with hyperglycemia mouse model,and the retinal vascular endothelial cells and pericytes were counted. Results Endothelial cells/ pericytes ratio in hyperglyce-mia group is significantly lower than that in normal group and form-deprivation myopia/amblyopia combined with hyperglycemia group. Con-clusion Form-deprivation myopia/amblyopia combined with hyperglycemia mice have more pericytes than hyperglycemia mice.%目的：本研究旨在明确形觉剥夺性近视/弱视是否通过保护视网膜微血管结构延缓糖尿病视网膜病变的发生发展。方法通过建立形觉剥夺性近视/弱视合并高血糖小鼠模型,并对成模小鼠、对照组、单纯高血糖组小鼠视网膜血管网进行铺片、计数周细胞、内皮细胞数量等观测,对观测数据进行统计学分析。结果高血糖组小鼠内皮细胞/周细胞比值较对照组显著降低(P<0.01),高血糖合并形觉剥夺组内皮细胞/周细胞比值较高血糖组有改善,3组相比有统计学差异(P<0.01)。结论形觉剥夺性近视合并高血糖小鼠模型的视网膜血管周细胞数量显著高于单纯高血糖模型组小鼠。