Objective To investigate the clinical efficacy of vertebral pedicle screw fixation for lumbar fractures without nerve injury. Methods A total of 100 patients with vertebral fractures from February 2012 to December 2012 in our hospital were researched.According to the order of the patient admitted to the hospital,50 patients from February 2012 to June 2012 were divided into observation group,50 pa-tients from 2012 July to December 2012 were divided into control group.The observation group were treated with vertebral pedicle screw fixa-tion,the control group were treated with a four nail fixation.The therapy and complications between two groups were compared after treatment, and the satisfaction of two groups were investigated.Results There was no significant difference in vertebral anterior height compression rate and Cobb angle between two groups before treatment(t =0.356 9,t =0.633 6,P =0.721 9,P =0.527 8),but after a week of treatment,ver-tebral anterior height compression rate and Cobb angle in observation group was better than those of the control group,the difference was sta-tistically significant(t =2.705 7,t =2.840 2,P =0.008 0,P =0.005 5).After one-year follow-up,there was no significant difference in effi-cacy between two groups(t =0.914 7,t =0.464 6,P =0.362 6,P =0.643 2).The postoperative complication rate of observation group was 4%,compared with 16% of control group,the difference was statistically significant (χ2 =4.000 0,P =0.045 5).The satisfaction rate of patient in observation group was 96%,compared with 84%of the control group,the difference was statistically significant (u =2.477 9,P =0.013 2). The fracturesof patients in two groups after 12 months were cured,without aggravating circumstances in nerve damage .Conclusion The ver-tebral pedicle screw fixation can effectively correct angular deformity,restore vertebral body height,strengthen the stability of the spine for treatment of patients with lumbar vertebrae without nerve injury.%目的：探讨经伤椎椎弓根螺钉置入内固定术治疗无神经损伤腰椎骨折的临床疗效。方法选择2012年2月至2012年12月我院收治的100例腰椎骨折的患者进行研究，按患者入院的先后顺序将2012年2月至6月治疗的50例患者作为观察组，将2012年7月至12月治疗的50例患者分为对照组。观察组患者采用伤椎椎弓根螺钉固定术进行治疗，对照组患者采用四钉固定术进行治疗。比较2组患者疗效及并发症情况，并对2组患者的满意度进行调查分析。结果治疗前，2组患者伤椎前缘高度压缩率以及 Cobb 角比较，差异无统计学意义（t ＝0．3569、0．6336，P ＝0．7219、0．5278），经过1周的治疗，观察组患者伤椎前缘高度压缩率以及 Cobb 角均优于对照组，差异具有统计学意义（t ＝2．7057、2．8402，P ＝0．0080、0．0055）。1年后的随访结果显示，2组患者的伤椎前缘高度压缩率以及 Cobb 角差异无统计学意义（t ＝0．9147、0．4646，P ＝0．3626、0．6432）；观察组患者在术后2周并发症的发生率为4％，与对照组的16％比较，差异具有统计学意义（χ2＝4．0000，P ＝0．0455）；观察组患者满意度高达96％，与对照组的84％比较，差异具有统计学意义（u ＝2．4779，P ＝0．0132）。2组患者在12个月后骨折均达到临床愈合，且无继发神经损伤加重情况。结论采用经伤椎椎弓根螺钉置入内固定术治疗无神经损伤腰椎骨折，可有效纠正成角畸形，恢复伤椎椎体高度，对脊柱稳定性有效地进行强化。
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