补救性肝移植和再次肝切除治疗肝癌术后复发的疗效对比

摘要

Objective To evaluate the curative effect of salvage liver transplantation and repeated hepatectomy for recurrent hepatocel-lular carcinoma.Methods The data of 72 patients with recurrent hepatocellular carcinoma fulfilling Child-Pugh A and the Milan criteria from September 2004 to August 2010 were retrospectively studied.According to different treatments,53 patients were divided into repeated hepatec-tomy group,and 19 patients were divided into salvage liver transplantation group.The overall survival rates and disease-free survival rates after operation were evaluated by Kaplan-Meier method.COX proportional hazard was used for univariate analysis and multivariate analysis to eval-uate the risk factors for prognosis.Results The 1-year,3-year and 5-year survival rates were 86.79%,62.26% and 45.28% in repeated hepatectomy group,and 89.47%,68.42%and 57.89% in the salvage liver transplantation group respectively.There was no significant differ-ence in the overall survival rates between the two groups (χ2 =2.530,P =0.112).The 1-year,3-year and 5-year disease-free survival rates were 67.92%,47.17% and 35.85%in the repeated hepatectomy group,94.74%,68.42% and 52.63% in the salvage liver transplantation group respectively.There was a significant difference in the disease-free survival rates between the two groups(χ2 =4.395,P =0.036).The univariate analysis and multivariate analysis indicated that microvascular invasion,satellite lesion and multiple tumors were the independent risk factors to influence the survival.Conclusion The salvage liver transplantation obtains a better effect for the patients fulfilling Child-Pugh A and the Milan criteria,which is an effective method in the treatment of hepatocellular carcinoma.%目的：探讨补救性肝移植和再次肝切除治疗肝癌切除术后复发的疗效。方法回顾性分析2004年9月至2010年8月72例符合米兰标准且肝功能为 Child A 肝癌复发患者的资料，依据手术方式不同分为再次肝切除组（53例）和补救性肝移植组（19例）。Kaplan-Meier 曲线检验2组患者肝癌切除术后复发的术后生存率和术后无瘤生存率的差异。COX 比例风险回归模型分析影响复发患者再次手术后生存的因素。结果再次肝切除组1年、3年、5年生存率为86．79％、62．26％、45．28％，补救性肝移植组治疗1年、3年、5年生存率为89．47％、68．42％、57．89％，2组比较差异无统计学意义（χ2＝2．530，P ＝0．112）；再次肝切除术组1年、3年、5年无瘤生存率分别为67．92％、47．17％、35．85％，补救性肝移植组1年、3年、5年无瘤生存率分别为94．74％、68．42％、52．63％，2组比较差异有统计学意义（χ2＝4．395，P ＝0．036）。单因素和多因素分析结果显示，微血管侵犯、卫星灶和肿瘤多发影响肝癌术后复发再次术后生存的独立危险因素。结论当肝癌术后复发符合米兰标准且肝功能为 Child A 时，补救性肝移植可取得稍优于再次肝切除治疗的效果，行补救性肝移植是一种可行有效的治疗方法。