解剖式肝段切除术在左肝胆管结石中的应用研究

摘要

目的：探讨解剖式肝段切除术在左肝胆管结石中的应用价值。方法将80例左肝胆管结石患者按照术式均分为对照组（n ＝40）与观察组（n ＝40），分别采用传统手术与精准肝蒂解剖式肝段切除术，比较2组患者手术指标水平、术后并发症发生率及手术前后应激反应水平。结果观察组术中出血量、手术时间、引流管拔除时间、镇痛药物使用时间及术后住院时间均少于对照组，差异具有统计学意义（P ＜0．05）。对照组术后并发症发生率为17．50％，观察组为15．00％，2组术后并发症发生率差异无统计学意义（P ＞0．05）。2组患者手术过程中肾上腺素、皮质醇、IL-6及 CRP 水平先升高后降低，NK 细胞水平先降低后升高，术后即刻至术后24 h 上述指标水平与术前水平差异均具有统计学意义（P ＜0．05），观察组术后即刻至术后24 h 上述指标水平变化程度小于对照组，差异具有统计学意义（P ＜0．05），术后48 h 上述指标恢复至术前水平。随访3～24个月，观察组结石复发率及上腹部隐痛发生率低于对照组，差异具有统计学意义（P ＜0．05）。结论精准肝蒂解剖式肝段切除术在左肝胆管结石中应用效果显著，对机体应激反应影响小。%Objective To investigate the application value of anatomic segmental hepatectomy in treatment of left hepatolithus.Methods The 80 patients with left hepatolithuswere divided into the control group (n =40)and the observation group (n =40)in accordance with dif-ferent surgical methods,and they were given traditional surgery and precise pedicle anatomic segmental hepatectomy respectively.Operation index levels,postoperative complications and stress reaction levels before and after surgery of the two groups were compared.Results The blood loss,operative time,the time of drainage tube remove,time of analgesic drug use,and postoperative hospital stay of the observation group were significantly less than the control group,and the difference was statistically significant (P <0.05).The rate of postoperative com-plications was 17.50% in the control group,while it was 15.00% in the observation group,which showed no significant difference between the two groups (P >0.05).During the surgery,epinephrine,cortisol,IL-6 and CRP levels of patients decreased after a slight increase, while NK cell levels of patients decreased firstly and then increased.There were statistically significant differences in trems of the above inde-xes immediately after surgery to 24 hours after surgery (P <0.05),and the rangeability of the observation group was less than the control group (P <0.05).Until 48 hours after surgery the above indexes recovered to the preoperative level.Followed up for 3 to 24 months,the calculi recurrence rate and abdominal ache recurrence rate of the observation group were lower than the control group,and the difference was statistically significant(P <0.05).Conclusion Precise pedicle anatomic segmental hepatectomy applied in the treatment of left hepatolithus showed makedly curative effect,and it has little effect on the stress response of patients.