不同剂量维生素D对Roux-en-Y胃旁路减重术后骨代谢异常的影响

摘要

Objective To determine the effect of different doses vitamin D supplementation to the change of bone metabolism in 6 months after Roux-en-Y gastric bypass ( RYGB) .Methods The change of body weight and body mass index ( BMI ) in 36 patients in 6 months after RYGB WAS analyzed.Then,the effect of low-dose (n=11,400 IU/day) and high-dose (n=12,1 600 IU/day) vitamin D to the serum calcium,25-hydroxyvitamin D and bone density were observed ,and 15 patients as control .Results In 6 months after RYGB,the body weight and BMI were decreased ,and the differences were statistical significance (P<0.05).The serum calcium,25-hydroxyvitamin D and bone density were increased in high-dose group,and the differences were statistical significance (P<0.05).Conclusion High-dose (1 600 IU/day) vitamin D supplementation is effective to the bone loss of patients undergoing RYGB .%目的：分析不同剂量维生素D补充对于Roux-en-Y胃旁路术（ RYGB）术后6个月患者骨密度的影响。方法将36例RYGB术后患者随机分为对照组（13例）、低剂量组（11例）和高剂量组（12例），观察不同剂量维生素 D （400 IU／d 和1600 IU／d）对患者术后6个月骨密度的影响并与对照组比较。结果术后6个月，入选研究对象体质量和身体质量指数（ BMI）在术后6个月均明显下降，差异有统计学意义（P＜0．05），其中1600 IU／d的维生素D补充治疗可升高术后患者的血钙和25-羟基-维生素D （25-hydroxyvitamin D，25[OH]D），同时骨密度明显增加，差异有统计学意义（P＜0．05）。结论 1600 IU／d的维生素D补充治疗对于PYGB术后的骨密度降低具有改善作用。