原发性高血压肾病患者血浆ET、leptin和血清APN水平的相关性分析

摘要

Objective To explore the correlativity between plasma ET; Leptin and serum APN levels in patients with primary hypertensive nephropathy. Methods plasma ET Leptin (with RIA) and serum APN(with ELISA) levels were measured in 32 patients with primary hypertensive nephrropathy; in 60 patients with essential hypension; but no nephropathy ; as well as in 35 healthy controls. Results plasma ET; Leptin levels in the patients were significantly higher than those in controls (P <0. 01); while the serum APN levels was markedly lower than those in controls (P <0.01); Meantime the serum APN levels were obviouly higher in subject with nephropathy( P < 0. 05 ) . The reverse was true for APN( P < 0. 05 ) simultaneously. Conclusion The development of primary hypertensive nephropathy was correlated with a higher ET; Leptin and lower serum APN levels. These useful biomarkers provide important clinical value.%目的:探讨了原发性高血压肾病患者血浆内皮素(ET)、瘦素(leptin)和血清脂联素(APN)水平的相关性.方法:分别应用放射免疫分析和酶联法对92例原发性高血压患者(其中32例伴肾病组,60例为无肾病组)进行了血浆ET、leptin、血清APN测定,并与35名健康人作比较.结果:原发性高血压无肾病组和肾病组血浆ET、leptin水平比较,均非常显著地高于正常人组(P＜0.01),而血清APN水平又明显低于正常人组(P＜0.01),原发性高血压肾病组与无肾病组亦有显著性差异(P＜0.01),结论:原发性高血压的发生与血浆ET、leptin和血清APN水平有十分密切的关系.这些实用的生物标志物可提供重要的临床价值.