目的:探讨原发性高血压肾病患者血浆ET-1和血清APN、CysC水平的变化及临床意义.方法:应用放射免疫分析和酶联法对32例原发性高血压肾病患者进行血浆ET-1和血清APN、CysC检测,并同时与35名正常人作比较.结果:原发性高血压肾病患者血浆ET-1和血清APN、CysC水平显著地高于正常人组(P<0.01),而血清APN水平又非常显著地低于正常人组(P＜0.01),血浆ET-1水平与CysC水平呈正相关(r=0.6228,P<0.01),与APN水平呈显著负相关(r=-0.4012,P<0.01).结论:检测原发性高血压肾病患者血浆ET-1和血清CysC、APN水平的变化,两者均具较高检测率.因此,有助于对疾病进程的评估,包括发病机制、预防和指导用药方针.%Objective To explore the clinical significance of changes on plasma ET-1 and serum CysC, AFN levels in patients with essential hypertension complicated with nephropathy. Methods Plasma ET-1 (with RIA) , serum CysC, APN(with ELISA) levels were measured in 32 patients with essential hypertension complicated with nephropathy prominently and compared to 35 normal controls simultaneously. Results Plasma ET-1 and serum CysC levels were significantly higher in the patients than those in controls(P < 0.01). while the serum APN level was remarkably lower(P<0. 01). Plasma ET-1 level was positively correlated with CysC(r = 0.6228,P<0.01). Plasma ET-1 level was significantly negatively correlated with APN(r= -0.4012,P <0.001). Conclusion Both the changes of plasma ET-1 and serum CysC, APN levels have high detection rete, thus might be helpful to the assessment of therndiseases process , such as pathogenesion, prevention and gurdlines fiorpharmacological therapy.
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