目的:为了探讨2型糖尿病(DM2)患者血脂、尿酸(SUA)和C-反应蛋白(CRP)测定的临床意义.方法:采用生化法测定了78例DM2患者和66例正常对照组的血脂(TC、TG、HDL-C和LDL-C)水平,过氧化物酶免疫分析测定了SUA水平以及免疫比浊法测定了CRP水平,并与66例正常对照组进行了对比性分析.结果:78例DM2患者的TC、TG和LDL-C水平较之66例正常对照组明显增加(P＜0.05～＜0.01),血清HDL-C水平明显降低(P＜0.01),尤以血清TG水平的增高和HDL-C水平的降低最为突出.36例DM2患者治疗明显好转后,血清TC和LDL-C恢复正常,TG水平明显降低(P＜0.05),HDL-C水平明显增高(P＜0.05),78例DM2患者的SUA和CRP水平较之66例正常对照组明显增高(P均＜0.01),36例DM2患者治疗明显好转后,SUA和CRP水平明显降低(P均＜0.05).结论:DM2患者不仅存在着血脂和尿酸代谢紊乱,而且也是一种低度炎症反应性疾病.血脂、SUA和CRP水平的动态观察是考核疗效有价值的指标.%Objective To expore the clinical significance of determining Hood lipid. Serum uric acid(SSU) and C-reactive protein(CRP) levels in patients with type 2 diabetes mellitus ( DM2) . Methods Blood lipid (with biochemistry); SUA(with peroxide enzyme immunoassay) and serum CRP(witth immunotuxbidimetry) levels were determined in 78 patients with DM2 and 66 normal controls and done comparative analysis. Results In Hood lipid analysis; serum TC; TG and LDL-C levels were significantly higher in 78 patients with DM2 than those in 66 controls(P<0.05 ～<0. 01) ; but serum HDL-C level was low(P <0. 01)before therapy. Serum TG levels increase and HDL-C levels decrease especially. After therapy; serum TC and LDL-C return to normal levels; serum TG was obviously low; but serum HDL-C level was notably increase. The SUA and serum CRP levels were significantly higher in 78 patients with DM2 than those in 66 controlsCP all <0.01) . After therapy; the SUA and serum CRP levels were remarkably low. Conclusion As in DM2; there existed blood lipid and uric acid metabolic disorder and manifested lower inflammatory reactive disease. The blood lip-id; serum SUA and CRP levels dynamic analysis might be used as an useful indicator to reflect the therapeutic effect.
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