Objective To investigate the relationship between the expression and clinical significance of mesothelin in breast invasive ductal cancer. Methods Mesothelin protein expressions in human breast invasive ductal cancer tissues determined by immuno-histochemistry. Results The positive percentages of mesothelin expression in breast invasive ductal cancer were 19. 6% . The positive percentages of mesothelin in breast invasive ductal cancer for surgical pathologic staging Ⅰ; Ⅱ; Ⅲ. Were 5. 56%; 12. 5%; 50%; respectively moreover; the relative contents of mesothelin in breast invasive ductal cancer for surgical pathologic staging Ⅲ.; with lymphatic metastasis were significantly higher than those in surgical pathologic staging 1; 1; without lymphatic metastasis; respectively (jP<0.05). Conclusion The expression of mesothelin is related to invasion and metastasis of in breast invasive ductal cancer; the detection of which may serve as an non-invasive indicator for the prediction and evaluation of malignancy and predicition of prognosis.%目的:研究间皮素(mesothelin)的表达与乳腺浸润性导管癌的关系.方法:采用免疫组化测定46例乳腺浸润性导管癌组织中mesothelin的表达情况.结果:mesothelin在乳腺浸润性导管癌组织中的阳性表达率为19.6% (9/46).在手术病理分期Ⅰ期、Ⅱ期和Ⅲ期中阳性率分别为5.56%、12.5%和50%.手术病理分期Ⅲ期、有淋巴结转移乳腺浸润性导管癌mesothelin的阳性率分别高于手术病理分期Ⅰ、Ⅱ期、无淋巴结转移(P<0.05).结论:mesothelin的表达与乳腺浸润性导管癌的病理分级、转移有关,检测其表达可作为一项非侵害性的指示物,有助于乳腺浸润性导管癌恶性程度的判断和预后的估计.
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