长期吸入糖皮质激素对支气管哮喘患者血清leptin、IL-13和IL-2水平的影响

摘要

目的:观察支气管哮喘患者血清leptin、IL-13和IL-2水平的变化并探讨长期吸入糖皮质激素后对支气管哮喘患者血清leptin、IL-13和IL-2的影响.方法:4采用酶联免疫吸附法(ELISA),分别检测70例支气管哮喘患者采用吸入糖皮质激素治疗前、治疗3、6、12个月后及60例对照者血清IL-13和IL-2水平;采用放射免疫分析血清leptin浓度.结果:支气管哮喘患者血清leptin、IL-13和IL-2水平显著高于正常对照组.吸入糖皮质激素治疗3个月后支气管哮喘患者血清leptin、IL-13和IL-2浓度与治疗前比较下降(P均＜0.05),治疗6个月和12个月后显著低于治疗前(P均＜0.01),且治疗12个月后各个炎症指标与对照组相比无显著性差异(P＞0.05).结论:长期吸入糖皮质激素是治疗支气管哮喘的重要手段,其治疗作用与下调血清leptin、IL-13和IL-2水平有关.%Objective To determine the effect of long-term inhalation of glucocorticoids on the level of leptin, IL-13, and H-2 in rnbronchial asthmatic patient. Methods End/me-linked immunosorbent assay ( ELISA ) was used to detect the serum IL-13 and IL-2 rnlevel in 60 healthy persons ( normal control group ) and 70 bronchial asthma patients untreated and 3, 6, 12 months pest-treatment,rnmeanwhile leptin was determined by radio immunoassay. Results The serum levels of leptin, IL-13, and IL-2 in were significantly rnincreased in patient with bronchial asthma compared with that in the normal control group. The serum levels of leptin, IL-13, and ILrn2 in children with asthma were clem'eased gradually after inhaling gineccortieoids for 3 months ( P < 0.05 ). The treatment of inhaled rnglucocortieoids for 6 and 12 months can attenuate the elevation of leptin, IL-13, and IL-2 compared with that before the treatment.rnConclusion Long-term inhaled glucoeortieoid is an important means for asthma, and the effects are related to the decrease of level of rnleptin, IL-13, and IL-2.