肺癌患者手术前后血清TGF-α、TGF-β1和SE-Cad检测的临床意义

摘要

目的:探讨了肺癌患者手术治疗前后血清TGF-α、TGF-β1和SE-Cad水平的变化及意义.方法:应用放射免疫分析和酶联法对32例肺癌患者进行了手术治疗前后血清TGF-α、TGF-β1和SE-Cad检测,并与35名正常健康人作比较.结果:肺癌患者在手术前血清TGF-α、TGF-β1和SE-Cad水平非常显著地高于正常人组(P＜0.01),经手术治疗6个月后则与正常人组比较无显著性差异(P＞0.05).结论:检测肺癌患者手术治疗前后血清TGF-α、TGF-β1和SE-Cad水平的变化对观察病情和预后判定具有重要的临床价值.%Objective To explore the significance of post-operative changes of serum TGF-a, TGF-|31 and SE-Cad levels in patients with lung cancer. Methods serum TGF-a,TGF-|31(with RIA) and serum SE-Cad(with ELISA) levels were determined both before and after operation in 32 patients with lung cancer and 35 normal healthy controls. Results Before operation the serum TGF-a, TGF-pl ftl SE-Cad levels in the patients were significantly higher than those in controls(P 0.05). Conclusion changes of serum TGF-a,TGF-J31 and SE-Cad contents after operation might be importance of monitoring pathosis and prognosis in patients with lung cancer clinically.