Objective To explore the clinical significance the measurement of changes of serum IL-10,IL-18 and E-selectin levels in patients with diabetic retinopathy. Methods Serum IL-10 (with RIA), serum IL-18, E-selectin(with ELBA) levels were measured in 32(NDR) , 30(DR) and 35 normal healthy controls. Results Serum IL-10,IL-18 and E-selectin levels in the patients with NDR and DR were significantly higher than those in controls. Serum IL-10 level was positively correlated with serum IL-18 and E-se-lectin levels(r =0.5084,06137,P<0.01). Conclusion Scrum IL-10,IL-18 and E-selectin play an important role in the pathogene-sis of diabetic retionpafliy. Detection of serum IL-10, IL-18 and E-selectin levels will be helpful for the diagnosis and therapy of diabetic retinopathy, thus provide certain value clinically.%目的:探讨糖尿病视网膜病变患者血清IL-10、IL-18和E-选择素水平的变化及临床意义.方法:应用放射免疫分析和酶联法对32例无糖尿病视网膜病变患者,30例伴视网膜病变患者进行了血清IL-10、IL-18和E-选择素检测,并与35名正常健康人作比较.结果:糖尿病患者无论有无视网膜病变,患者血清IL-10、IL-18和E-选择素水平均显著地高于正常人组(P<0.01),血清IL-10水平与IL-18和E-选择素水平呈正相关(r=0.5084、06137,P<0.01).结论:血清IL-10、IL-18和E-选择素参与了糖尿病视网膜病变的发病机制,检测血清IL-10、IL-18和E-选择素水平的变化有助于糖尿病视网膜病变的诊断,有一定的临床价值.
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