支气管哮喘患者不同发作时期外周血 OX40／OX40 L的表达及阿奇霉素的干预效果研究

摘要

目的：观察支气管哮喘患者不同发作时期外周血OX40/OX40L的表达情况，探讨阿奇霉素的干预效果。方法选择我科收治的72例支气管哮喘患者，根据所处的不同时期进行分组，其中急性发作期-称为Ⅰ组，缓解期-称为Ⅱ组。检测两组患者外周血OX40/OX40L变化，治疗后两组患者FEV1％、ACT、EOS以及IgE情况。结果与Ⅱ组比较，Ⅰ组的OX40在CD4＋T细胞表达的比例降低明显，差异具有统计学意义（P＜0．05），在CD8＋T细胞表达的比例增加，差异不具有统计学意义（P＞0．05）；与Ⅱ组比较，Ⅰ组的OX40L表达增加明显，差异具有统计学意义（P＜0．05），Ⅰ组组间比较可见，随着病情程度的加重，OX40L表达呈现不断增加的趋势；与Ⅱ组比较，Ⅰ组的FEV1％、ACT降低明显，EOS、IgE水平则增加明显，差异均具有统计学意义（P＜0．05）。结论支气管哮喘患者外周血中OX40/OX40L异常增加，其与患者病情的严重程度具有相关性，阿奇霉素可有效改善支气管哮喘患者的临床症状，适宜临床推广。%Objective To observe the expression of OX40/OX40L in peripheral blood of bronchial asthma patients who at different episode , and discuss the intervention effect of Archie enzyme .Methods 72 cases of bronchial asthma patients who received therapy in our department were selected , they were dividedinto acute-outbreak period (short for Ⅰgroup) and paracmasis (short for Ⅱgroup)according to different episode . We tested OX40/OX40L the expression in peripheral blood , FEV1 %, ACT, EOS and IgE of the patients after treatment.Results OX40 expression in CD4+T cells in groupⅠsignificantly less than that in groupⅡ( P<0. 05), however, OX40 expression in CD8+T cells in groupⅠsignificantly more than that in groupⅡ(P<0.05). OX40L expression in groupⅠsignificantly more than that in groupⅡ(P<0.05).And the expression of OX40L increased as the increasing severity of illness .FEV1 % and ACT of group Ⅰwere more than those of groupⅡ, but EOS and IgE levels at the oppositecondition , the differences had statistically significances ( P <0.05). Conclusions OX40/OX40L abnormal increased in peripheral blood of Bronchial asthma patients when it broke out and had relativity with disease severity .Archie enzyme could effectively improved clinical symptom of bronchial asthma patients , worth of clinical application .