首页> 外国专利> METHOD FOR ASSESSING IMMUNITY AND PROVIDING INFORMATION ON WHETHER OR NOT THE ONSET OF CANCER HAS BEGUN BY UTILIZING DIFFERENCE IN IMMUNE CELL DISTRIBUTION BETWEEN PERIPHERAL BLOOD OF COLORECTAL CANCER PATIENT AND NORMAL PERSON, AND DIAGNOSTIC KIT USING SAME

METHOD FOR ASSESSING IMMUNITY AND PROVIDING INFORMATION ON WHETHER OR NOT THE ONSET OF CANCER HAS BEGUN BY UTILIZING DIFFERENCE IN IMMUNE CELL DISTRIBUTION BETWEEN PERIPHERAL BLOOD OF COLORECTAL CANCER PATIENT AND NORMAL PERSON, AND DIAGNOSTIC KIT USING SAME

机译:通过利用大肠癌患者外周血与正常人的外周血之间的免疫细胞分布差异,以及使用相同的诊断试剂盒来评估免疫力并提供有关癌症发作的信息的方法

摘要

Provided according to the present invention is a method for assessing immunity of peripheral blood and providing information on whether or not the onset of colorectal cancer has begun by utilizing a difference in immune cell distribution between peripheral blood of colorectal cancer patients and normal persons, the method comprising the steps of: (A) analyzing peripheral blood immune cells for cell size and wrinkle degree to classify the cells into lymphocytes, monocytes, and granulocytes; (B) staining a labeling marker of the three kinds of immune cells with at least one antibody combination to analyze the distribution of immune cells in peripheral bloods of cancer patients and normal persons; (C) discriminating sets in which meaningful result values of the labeling marker are different between the two groups, cancer patients and normal persons, with statistical significance, so as to discriminate whether or not the onset of cancer has begun among cancer patients and normal persons; and (D) measuring immunity per unit of blood by means of the labeling marker to diagnose whether or not the onset of colorectal cancer has begun, without counting natural killer cells with a flow cytometer or a cell counter.
机译:根据本发明,提供了一种通过利用结直肠癌患者和正常人的外周血之间的免疫细胞分布的差异来评估外周血的免疫力并提供关于是否已经开始结直肠癌的信息的方法,该方法包括以下步骤:(A)分析外周血免疫细胞的细胞大小和皱纹程度,以将细胞分类为淋巴细胞,单核细胞和粒细胞。 (B)用至少一种抗体组合对三种免疫细胞的标记物进行染色,以分析免疫细胞在癌症患者和正常人外周血中的分布; (C)在癌症患者和正常人这两组之间区分标记标记的有意义结果值不同的集合,具有统计学意义,从而区分癌症患者和正常人是否已经开始癌症发作。 ; (D)通过标记标记物测量每单位血液的免疫力,以诊断大肠癌的发作是否已经开始,而不用流式细胞仪或细胞计数器来计数自然杀伤细胞。

著录项

  • 公开/公告号WO2018221820A1

    专利类型

  • 公开/公告日2018-12-06

    原文格式PDF

  • 申请/专利权人 LEE JONG KYUN;

    申请/专利号WO2018KR00505

  • 发明设计人 CHOI JOUNG BUM;

    申请日2018-01-11

  • 分类号G01N33/574;G01N33/58;G01N33/569;G01N15/14;

  • 国家 WO

  • 入库时间 2022-08-21 11:57:54

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