Objective To study the efficacy and safety of telmisartan combined with hydrochlorothiazide in the treatment of hypertension patients in community .Methods 100 cases of primary hypertension patients got therapy during January 2015 to January 2016 were divided into control group (50 cases) and experimental group (50 cases).The control group was treated with hydrochlorothiazide , while the experimental group was treated with telmisartan and hydrochlorothiazide .The treatment effects and adverse reactions of the two groups were observed . Results The total effective rate of the treatment group was 100%, significantly higher than that of the control group (82%), there was statistical significance (P<0.05).The blood pressure level of the experimental group at 2, 4 and 12 weeks after treatment was better than that before treatment , as well as better than that of control group ( P<0.05) .There were none low blood potassium in the experimental group , the incidence of low blood potassium in control group was 12%, there was statistical significance (P<0.05).Conclusions Telmisartan combined with hydrogen hydrochlorothiazide in the treatment of community patients with hypertension , the effect is exact , it can effectively stabilize blood pressure fluctuations , high safety for medication , so it is worth popularization and application in the group of patients with hypertension in community .%目的：研究替米沙坦联合氢氯噻嗪治疗社区高血压患者的疗效及安全性。方法将2015年1月至2016年1月收治的100例原发性高血压患者分为对照组（50例）与实验组（50例）。对照组单用氢氯噻嗪，实验组采用替米沙坦联合氢氯噻嗪。评估两组降压疗效并对比不良反应。结果实验组患者的治疗总有效率100％，明显比对照组82．0％更高，组间差异具有统计学意义（ P＜0．05）。实验组治疗后2周、4周和12周时的血压水平控制较治疗前比对照组更佳（ P＜0．05）。实验组中无1例低血钾，对照组低血钾发生率为12．0％，差异显著（ P＜0．05）。结论替米沙坦联合氢氯噻嗪治疗社区高血压患者效果确切，可有效稳固患者血压波动，用药安全性较高，值得在社区高血压患者群体中推广应用。
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