精神分裂症前瞻记忆与精神症状的相关性

摘要

目的 研究精神分裂症患者基于事件前瞻记忆(EBPM)和基于时间前瞻记忆(TBPM)改变的特征,探讨患者前瞻记忆与精神症状的相关性.方法 采用前瞻记忆神经心理学测验方法,对52例精神分裂症患者患者组以及年龄、性别、受教育程度相匹配的47名正常对照者(正常对照组)进行测试.并用阳性与阴性症状量表(PANSS)评估这些患者的精神症状.结果 正常对照组[EBPM:(5.28±0.83)分、TBPM:(5.15 ±0.88)分]与患者组EBPM成绩[(4.15±1.09)分]和TBPM成绩[(3.29±1.49)分]比较差异有显著性(t=-5.72,P＜0.01；t=-7.60,P＜0.01).控制药物剂量后的偏相关分析显示,患者EBPM成绩和TBPM成绩分别同阳性与阴性症状量表总分及阴性症状量表分呈负相关.结论 精神分裂症患者存在前瞻记忆损害,患者前瞻记忆与其精神症状存在相关性.%Objective To investigate the event-based prospective memory ( EBPM) and time-based prospective memory (TBPM) in patients with schizophrenia, and to explore the relationship between prospective memory and symptomatology. Methods A total of 52 schizophrenic patients and 47 healthy controls matched in age, gender and education were assessed with a neuropsychological battery of tests including EBPM and TBPM tasks. Positive and Negative Syndrome Scale ( PANSS) was used to evaluate their symptomatology. Results Compared with normal controls (EBPM 5. 28 ±0. 83, TBPM 5. 15 ±0. 88) , patients with schizophrenia showed significantly impaired EBPM (4. 15 ± 1.09, t= -5.72, P<0.01) and TBPM (3.29±1.49, t= -7.60, P < 0.01). After controlling for antipsychotics, the EBPM and TBPM in patients were significantly negatively correlated with the total score of PANSS and score of Scale for the Assessment of Negative Symptoms (SANS). Conclusion Patients with schizophrenia have impaired prospective memory, which is related with their symptomatology.