创伤后应激障碍患者血清吲哚胺2，3-双加氧酶表达变化及意义

摘要

目的：初步探讨创伤后应激障碍（ PTSD）患者血清中干扰素-γ（ INF-γ）、肿瘤坏死因子-α（ TNF-α）、白介素-6（IL-6）与吲哚胺2，3-双加氧酶（IDO）表达变化及意义。方法收集80例PTSD患者（研究组）与80例正常对照者（对照组），采用酶联免疫吸附法（ ELISA）与Western Blot方法对两组血清中INF-γ、TNF-α、IL-6及IDO进行检测并比较。结果研究组血清INF-γ、TNF-α、IL-6及IDO均高于对照组（P＜0．05）。结论 PTSD患者存在显著的免疫功能紊乱，INF-γ、TNF-α、IL-6及IDO可能在PTSD的发病机理中起着重要作用。%Objective To explore the expression change and significance of serum interferon-γ( INF-γ) , tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and indoleamine 2,3-dioxy-genase (IDO) in patients with post-traumatic stress disorder (PTSD).Methods 80PTSDpatients(studygroup)and80healthycontrols(controlgroup)wereassessedwithenzyme-linked immunosorbent assay ( ELISA) and Western Blot to detect and compare the serum levels of INF-γ, TNF-α, IL-6 and IDO. Results Serum levels of INF-γ, TNF-α, IL-6 and IDO in study group were significantly higher than those in control group ( P<0.05).Conclusion Noticeable immune dysfunctions may exist in PTSD patients.INF-γ, TNF-α, IL-6 and IDO may play an important role in the pathogenesis of PTSD.