青少年孤独症静息态脑突显网络的功能影像学研究

摘要

目的：探讨青少年孤独症患者的脑突显网络的异常。方法对15例青少年孤独症患者（研究组）和15名健康对照者（对照组）进行3．0T静息态脑功能磁共振扫描，使用独立成分分析法对影像学结果进行分析。结果与对照组相比，研究组突显网络的左眶部额下回、左距状裂周围皮层、左额中回、右楔叶功能连通性减弱，右颞下回、右海马旁回、右枕中回功能连通性增强。结论青少年孤独症患者的静息态脑突显网络存在多个脑区的功能连通性改变。%Objective To explore the abnormal function in the brain resting-state salience network for adolescents with autism.Methods A total of 15 adolescents with autism in study group and 15 healthy adolescents in control group were examined with the 3.0T resting-state Functional Magnetic Resonance Imaging ( fMRI ) and the results were analyzed with independent component analysis.Results The functional connectivities on Frontal-Inf-Orb-L, Calcarine-L, Frontal-Mid-L and Cuneus-R in study group were all significantly lower than those in control group, but the functional connectivities on Temporal-nf-R, ParaHippocampal-R and Occipital-Mid-R in study group were significantly higher than those in control group.Conclusion There are abnormal functions for the brain resting-state salience network on some encephalic regions in the adolescents with autism.