2010～2015年北京安定医院儿童青少年精神分裂症住院患者药物使用分析

摘要

Objective To analyze the psychiatric medications in children and adolescents with schizophrenia of Beijing Anding Hospital from 2010 to 2015.Methods The children and adolescents with schizophrenia of Beijing Anding Hospital from 2010 to 2015 were selected and their psychiatric medications were retrospectively analyzed when they left hospital.Results A total of 507 children and adolescents with schizophrenia were selected and the antipsychotics which were singly taken by the inpatients included olanzapine,risperidone,paliperidone,amisulpride,aripiprazole and so on.The dosage of risperidone in the adolescents was significantly higher than that in the children (P ＜ 0.05),and the dosages of olanzapine,aripiprazole,sulpiride in the inpatients taking single antipsychotics were all significantly higher than those in the inpatients taking combination with other antipsychotics (P ＜ 0.05).In the combination with other psychiatric medication,there were valproate for mood stabilizer,sertraline for antidepressant and lorazepam for anxiolytic.Conclusion There are atypical antipsychotics as the mainly single treatment in the children and adolescents with schizophrenia and the dosages of the antipsychotics are made according to the age and combination of medication in the patients.%目的 分析2010 ～2015年北京安定医院儿童青少年精神分裂症患者药物使用情况.方法 回顾分析2010～2015年北京安定医院儿童青少年精神分裂症患者出院当日使用药物情况.结果 共有507例患者入组,单一使用抗精神病药物频率前5依次为奥氮平、利培酮、帕利哌酮缓释片、氨磺必利、阿立哌唑,其中青少年组使用利培酮的剂量显著高于儿童组(P＜0.05),奥氮平、阿立哌唑、舒必利单一使用剂量显著高于合并使用剂量(P＜0.05).抗精神病药合用情感稳定剂以丙戊酸盐为主,合用抗抑郁药以舍曲林为主,合用抗焦虑药以劳拉西泮为主.结论 儿童青少年精神分裂症住院患者以单一使用非典型抗精神病药为主,不同年龄及合并用药时注意选择药物剂量.