健脾清化汤联合奥硝唑及克拉霉素治疗幽门螺旋杆菌感染临床观察

摘要

Objective:To explore the clinical therapeutic effect of Jianpi Qinghua Decoction combined with ornidazole and clarithromycin in the treatment of Helicobacter pylori (HP) infection.Method:A total of 147 HP infection patients were divided into 2 groups randomly.The routine treatment group (n=75) were treated with ornidazole and clarithromycin while the combined group (n=72) were treated with Jianpi Qinghua Decoction on the basis of the treatment of the routine group.Before and after the treatment, C14 breath test was performed to compare the HP positive rate and clinical efficacy between the two groups.Result:There's statistical significance in the disappearance time of the different symptoms between the combined group and the routine treatment group (P<0.05) .The positive detection rate of Hp in the two groups was significantly different from that before treatment and the improvement effect of Hp infection in the combined group was significantly superior to that in the routine treatment group (P<0.05) .The clinical therapeutic effect of the combined group was significantly superior to that of the routine treatment group (P<0.05) , but there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05) .Conclusion:Conversational western medicine has a certain therapeutic effect in the treatment of HP infection, but in this study which combined with traditional Chinese medicine formula has further improved the therapeutic effect.At the same time, the patient's symptom improvement time is significantly shortened, which helps to improve the patient's treatment compliance and reduce their painful feelings.Jianpi Qinghua Decoction combined with ornidazole and clarithromycin is safe and effective in the treatment of HP infection patients and can be considered as a clinical treatment plan.%目的:观察健脾清化汤联合奥硝唑及克拉霉素治疗幽门螺旋杆菌 (HP) 感染的临床疗效.方法:147例随机分为两组, 常规组75例给予奥硝唑及克拉霉素治疗, 联合组72例加用健脾清化汤治疗, 观察治疗前后行C14呼气试验检查, 比较两组Hp阳性率及临床疗效.结果:两组症状消失时间比较差异有统计学意义 (P<0.05) .两组Hp阳性检出率同治疗前比较差异有统计学意义 (P<0.05) , 且联合组Hp感染改善效果优于常规组 (P<0.05) .总有效率联合组高于常规组 (P<0.05) .结论:健脾清化汤联合奥硝唑及克拉霉素治疗Hp感染可提高疗效, 缩短症状改善时间, 有利于提高治疗依从性.