MAC30蛋白在口腔鳞状细胞癌中的表达及其临床意义

摘要

检测20例正常口腔黏膜和43例口腔鳞状细胞癌患者MAC30蛋白的表达情况.MAC30蛋白在口腔鳞状细胞癌中的表达较正常黏膜明显增加(p＜0.05)；低分化组和淋巴结转移组较高分化组及淋巴结无转移组阳性表达率明显增高(P＜ 0.05)；MAC30蛋白在口腔鳞状细胞癌的发生、发展、分化及转移过程中可能起着重要作用,并可作为一个预测肿瘤转移的新的分子生物学指标.%MAC30 protein expression was examined by immunohistochemical ABC method in 20 cases of normal oral mucous tissue and 43 cases of oral squamous cell carcinoma( OSCC). MAC30 expression level in OSCC was higher than in normal mucosa(P <0. 05 ). MAC30 expression level in patients with lymph node metastasis and/or with low differentiation was higher than in those without lymph node metastasis and/or with high differentiation (P <0. 05). MAC30 may play an important role in the tumorgenesis, development and metastasis of OSCC.