牙釉质表面原位再生釉质六棱柱样含氟磷灰石显微结构

摘要

目的:用简单化学方法在牙釉质表面原位合成形态可控的类釉质样氟磷灰石结构,模拟牙齿的自然组成及形貌.方法:以常见的化学原料乙二胺四乙酸二钠钙(EDTA-Ca-Na2)、磷酸二氢钠单水化合物(NaH2 PO4·H20)以及氟化钠作为原料,形成前躯体后与基板同时在温和水热条件中相互作用一段时间获得材料.用X射线衍射、红外光谱、扫描电镜、X线电子能谱、MTT实验、抑菌环实验等评价新材料的理化及生物学性能,对变形链球菌有抑制作用.结果:形成的物质主要成分是氟磷灰石,呈典型的六棱柱结构,横截面直径为300 nm、长约6μm,大小均匀,并且呈现一定的长轴取向性.结论:新型材料能够初步模拟牙釉质的形貌、组成,并有一定抑菌功物.%Objective: To construct fluoridated hydroxyapatite (FA) enamel prism-like structure on the natural enamel surface of human teeth by a simple chemical approach. Methods: FA enamel prism-like structure with different sizes and shapes were produced on the enamel surface of human teeth by a chemical approach using EDTA-Ca-Na2, NaH2PO4 · H2O and NaF as the react-ants. The physicochemical and biological properties of the enamel-like material were studied by SEM, XRD, FTIR, XPS, MTT assay and bacterial inhibition ring test. Results: The compacted well-aligned FA crystals were produced, which could grow directly on the enamel surface. The nanorods of the crystal were approximately 6 (Jim in length and 300 nm in diameter whose physicochemical property and biological performance were similar to those of natural enamel. The enamel-like material showed biocompatibility and certain bacteriostasis. Conclusion: The FA product may simulate the structure, component and decay resistance of human tooth enamel.