Objective: To invesligale the expression of decoy receplor 3( DcR3) in salivary gland tumors and its clinicopalhological significance. Methods: Immunohislochemslry and in situ hybridization were used to examine the expression of DcR3 in salivary gland lumors. The relationship belween DcR3 expression and clinicopalhological parameters of the lumors was analysed. Results : The expression of DcR3 was found mainly in the cyloplasm of epithelial cells of salivary gland lumors and the corrugated lube and leap lube of normal salivary gland, ils expression was higher in malignant salivary gland lumors than in benign lumors( P <0. 05) , and that was related lo malignant degree and nodal metastasis of malignant lumors ( P <0. 05) , the expression of DcR3 protein was significantly correlated with DcR3 mRNA in the tumors( P < 0. 01) . Conclusion: DcR3 may play a role in lumorigenesis and development of salivary gland lumors.%目的:探讨诱骗受体3(DcR3)在涎腺肿瘤中的表达及其临床病理意义.方法:通过免疫组化和原位杂交法检测涎腺肿瘤中DcR3的表达情况,并分析其表达与患者临床病理参数的关系.结果:DcR3主要表达在涎腺肿瘤的肿瘤性上皮细胞胞质和正常涎腺闰管和纹管的细胞质中;DcR3在恶性涎腺肿瘤中的表达高于良性肿瘤(P<0.05);DcR3在恶性涎腺肿瘤中的表达与其恶性程度和淋巴结转移有关(P<0.05);DcR3蛋白和mRNA的表达显著相关(P<0.01).结论:DcR3可能参与了涎腺肿瘤的发生发展.
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