口腔黏膜下纤维化组织中缺氧诱导因子-1α的表达

摘要

目的：探讨HIF-1α在口腔黏膜下纤维化（OSF）中的作用。方法：采用免疫组化SP法，用缺氧诱导因子-1α（HIF-1α）兔抗人多克隆抗体检测30例OSF患者及5例正常对照者口腔黏膜组织中HIF-1α蛋白的分布。结果：HIF-1α蛋白在正常口腔黏膜中为阴性表达，在OSF病变组织中阳性表达（P＜0．05）。结论：OSF的发病机制中可能起着重要作用。%Objective:To evaluate the effects of HIF-1αprotein in the pathogenesis of oral submucous fibrosis(OSF)tissue.Meth-ods:HIF-1αprotein expression in 30 cases of OSF,5 cases of normale control oral mucosa tissue was studied by SP immunohisto-chemistry with HIF-1αrabbit anti-human polyclonal antibody.Results:The negative expression of HIF-1αwas found in normal oral mucoa tissue and possitive in early,intermediate and advanced stage of OSF(P<0.05 ).Conclusion:HIF-1αprotein may play an importent role in the pathogenesis of OSF.