磁共振成像研究膝股骨髁软骨T2值空间分布

摘要

Objective To study the spatial variation of T2 relaxation time (T2 value) of femoral condyle cartilage of knee in the healthy adults and early osteoarthritis(OA) patients. Methods T2 values of femoral condyle cartilage were evaluated with Siemens 3. 0 T MR in 25 healthy knee joints (20 subjects,age ranged:25 - 38 years with mean age 28. 7 + 4. 5 years) and 31 knee joints with early osteoarthritis(OA) (27 subjects,age ranged:40 - 78 years with mean age 54. 2 + 11 years). T2 values of non-weight-bearing site and weigh-bearing site of medial femoral condyle and lateral femoral condyle were measured respectively on T2-mapping images. Statistical differences were analyzed. Results T2 values of weight-bearing site of femoral condyle were higher obviously than that of non-weight-bearing site in healthy group and early OA group, there were significant differences between them(.F=22. 151,54. 670 ,P <0. 05). Significant differences were found for the spatial variation in healthy group (F=27. 960,12. 972,12. 718,7. 837,P<0. 05). In early OA group,zonal variation of T2 value was significant at the non-weight-bearing site(F=6. 062,10. 436,P<0. 05). No significant differences were found in T2 values between superficial and deep zone at the weight-bearing site(.F=l. 208,1. 472,P>0. 05). Conclusion The spatial variation of T2 value of femoral condyle cartilage of knee in the healthy adults and early OA patients is of certain characteristics,that is of reference value in monitoring cartilage change of early OA. And T2 value is influenced by the weight bearing condition.%目的 研究健康成人和早期骨性关节炎(osteoarthritis,OA)病人膝关节股骨内外髁软骨横向弛豫时间(T2值)空间分布.方法 采用Siemens 3.0T磁共振,正常组(20例;年龄25~38岁,平均28.7岁±4.5岁)25个膝关节和早期OA病人组(27例;年龄40~78岁,平均54.2岁±11岁)31个膝关节,应用T2图成像观察和测量2组股骨内外侧髁非负重区与负重区软骨T2值,并进行统计学分析.结果 正常组与早期OA组股骨髁负重区软骨平均T2值[(51.1±4.3) ms,(58.9±4.0) ms]明显高于各自非负重区[(47.2±3.8) ms,(53.5±4.1) ms],差异有统计学意义(F值分别为22.151和54.670,P值均<0.05);正常组股骨髁各区软骨浅层T2值明显高于深层,差异有统计学意义(F值分别为27.960、12.972、12.718、7.837,P值均<0.05);早期OA组股骨内外髁非负重区软骨浅层T2值明显高于深层(F值分别为6.062和10.436,P值均<0.05),负重区软骨浅层与深层比较差异无统计学意义(F值分别为1.208和1.472,P值均>0.05).结论 健康成人和早期OA病人膝关节股骨内外髁软骨T2值具有特定空间分布特点,对量化监测早期OA软骨病变具有参考价值.负重对软骨T2值空间分布有一定影响.