Objective To investigate the clinical value of transcatheter hepatic arterial chemoembolization(TACE) combined por-tal vein embolization (PVE) treatment for advanced hepatocellular carcinoma. Methods All of the articles about randomized con-trolled trials (RCT) or non-randomized concurrent control trials (CCT) in the treatment of advanced hepatocellular carcinoma be-tween TACE alone and TACE combined PVE were collected. In accordance with criteria, the literatures were evaluated and selected into the Meta-analysis. Results A total of 10 literatures and 1078 cases were included. The extracted data were analyzed with Meta by the software RevMan 5. 1. The results were as follows: (1) Complete remission rates and partial remission rates of solid tumors of patients in the experimental group were better than those in the control group. (2) Disappearance rates and shrink rates of portal vein tumor thrombus in the experimental group were higher than those in the control group. (3) Alpha-fetoprotein (AFP) decre-ment rates by the value of 50 % in the experimental group were higher than those in the control group. Conclusion This study sug-gests that the treatment of TACE combined PVE for advanced hepatocellular carcinoma can improve the treatment efficacy in con-trast to the simple treatment of TACE.%目的 探讨经导管肝动脉化疗栓塞术(TACE)联合门静脉栓塞术(PVE)治疗中晚期肝癌的临床价值.方法 收集国内外所有关于中晚期肝癌应用TACE联合PVE治疗与单纯TACE治疗的随机对照试验(RCT)或非随机同期对照试验(CCT)方面的文章,根据选择标准确定纳入Meta分析的文献,对所有纳入文献的原始数据进行Meta分析.结果 共有10篇文献、1 078例病例被纳入.提取数据后,运用RevMan 5.1软件进行Meta分析.得到分析结果如下:(1) 试验组患者的实体瘤完全缓解率及部分缓解率均好于对照组;(2) 试验组患者的门静脉癌栓消失率及缩小率均高于对照组;(3) 试验组患者甲胎蛋白(AFP)值下降50%的比率高于对照组.结论 相对于单纯TACE治疗,TACE联合PVE治疗中晚期肝癌,能明显提高患者的疗效.
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