Wernicke脑病的MRI表现

摘要

目的 探讨Wernicke脑病(Wernicke's encephalopathy,WE)的MRI表现,以提高诊断水平.方法 收集临床确诊并具有完整MRI资料的11例WE进行回顾性分析.结果 5例病变对称性分布于丘脑内侧、第三脑室周围灰质及乳头体.3例病变位于第三脑室周围灰质、中脑导水管周围灰质.2例病变位于中脑导水管周围灰质、丘脑内侧并乳头体萎缩.1例病变位于丘脑内侧、第三脑室周围灰质及顶枕叶皮质区.病变于T1WI为等或低信号,T2WI表现为高信号;FLAIR序列呈高信号;4例急性期病变DWI图像呈高信号.2例增强扫描病例示乳头体呈结节状强化.结论 WE具有典型的MRI表现,对临床诊断有重要意义.%Objective To explore MRI features of Wernicke encephalopathy in order to improve accurate rate of diagnosis of this disease. Methods MRI data of Wernicke encephalopathy in 11 cases were retrospectively analyzed. Results The lesions were sym-metrically located at medial thalamus, the grey matter surrounding the third ventricle and mammillary body in 5 cases, at the grey matter surrounding the third cerebral ventricle and aqueduct in 3 cases,at the grey matter surrounding aqueduct and medial thalamus with mammillary body atrophy in 2 cases, at medial thalamus and the grey matter surrounding the third cerebral ventricle in 1 case with the cortex of parietal and occipital lobe involved. The lesions appeared as isointensity or hypointensity on T1 WI, hyperintensity on T2 WI and FLAIR. In 4 acute cases, the lesions appeared as hyperintensity on DWI. Mammillary body showed nodular enhance-ment in 2 cases after administration of contrast medium. Conclusion Wernicke encephalopathy has typical features on MRI, which provide great value in clinical diagnosis.