Objective: The clinical epidemiologicai investigation of the patients with pregnancy-induced hypertension in the first affiliated hospital of Chongqing medical university was done from January 2004 to December 2010,in order to explore the situation of pregnancy-induced hypertension in recent years . Methods: The retrospective analysis of 523 cases of pregnancy-induced hypertension from January 2004 to December 2010 was carried out, including general features,maternal and infant complications,delivery modes, perinatal pregnancy outcomes and biochemical parameters. Results:The gestational weeks of disease onset became earlier(F=14.79,P＜0.01) ,the numbers of severe preeclampsia and eclampsia increased markedly(x2 = 91.85,P＜0.01). Regular antenatal examination bacame more popular(x2 = 34. 93,P＜0. 01), and the propotion of rural population became bigger(x2 =50.20,P＜0.01). Cesarean section was still the main delivery mode (x2 =37.06,P＜0.01). Neonatal Apgar score and weight decreased along with the severity of PIH (P＜0.01). The levels of lactic dehydrogenasexalkaline phosphatase and uric acid increased along with the severity of PIH, while blood calcium decreased markedly. Conclutions: Pregnancy-induced hypertension in our hospital showed a tendency of onset earlier and more severe manifestation, while the adverse maternal and neonatal outcomes still maintain a stable level.%目的:对妊娠期高血压疾病患者进行临床流行病学调查分析,以了解近年来我院妊娠期高血压疾病的情况.方法:对我院2004年1月至2010年12月收治的523例妊娠期高血压疾病患者的基本情况、母婴并发症、分娩方式、围生儿结局、生化指标等进行回顾性分析.结果:近7年来妊娠期高血压疾病的发病孕周有提前趋势(F=14.79,P＜0.01),重度妊娠期高血压疾病的发生率呈上升趋势(X 2 =91.85,P＜0.01),规律产前检查孕妇比例呈上升趋势(X 2=34.93,P＜0.01),乡村人口所占比例有增加趋势(X 2=50.20,P＜0.01),分娩方式仍以剖宫产为主(X2 =37.06,P＜0.01).新生儿Apgar评分、新生儿体重随妊娠期高血压疾病病情加重有降低趋势(P＜0.01).乳酸脱氢酶、碱性磷酸酶、尿酸指标随病情加重有增高趋势,血钙随病情加重有降低趋势.结论:我院7年来妊娠期高血压疾病有早发、加重的趋势,但母儿不良结局无升高趋势.
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