DPPⅣ蛋白和Seprase蛋白在卵巢上皮性癌中的表达及意义

摘要

Objective:To determine the expression and significance of DPPIV and Seprase protein in human epithelium ovarian cancer. Methods:The expressions of DPPIV and seprase were detected by immu-nohistochemistry in 128 cases of ovarian epithelium cancer, 41 cases of ovarian borderline tumor and 30 cases of benign ovarian tumor. Results:The expression rate of DPPIV in ovarian cancer was 82.81%, which was much higher than those in borderline tumor(56.10%) and benign tumor(16.67%) ,the differences were significant P < 0. 05). The expression rate of Seprase in ovarian cancer was 85. 94%, which was much higher than those in borderline(60. 98%)and benign tumor(20. 00%),the differences were significant P< 0. 05). The expressions of DPPIV and Seprase in ovarian cancer were correlated with the clinical stages and lymphatic metastases. Conclusions: DPPIV and Seprase protein involve in the carcinogenesis and development of ovarian cancer, may be the diagnostic marker and potential therapeutic target.%目的:探讨二肽基肽酶Ⅳ( DPPⅣ)蛋白和Seprase蛋白在卵巢上皮性癌中的表达及意义.方法:免疫组化法检测DPPⅣ蛋白和Seprase蛋白在128例卵巢上皮性癌、41例卵巢交界性肿瘤和30例卵巢良性肿瘤组织的表达.结果:DPPⅣ蛋白在卵巢上皮性癌组织的阳性表达率为(82.81％),显著高于卵巢交界性肿瘤(56.10％)及卵巢良性肿瘤(16.67％),差异有统计学意义(P＜0.05)；Seprase蛋白在卵巢上皮性癌组织的阳性表达率为(85.94％),显著高于卵巢交界性肿瘤(60.98％)及卵巢良性肿瘤(20.00％),差异有统计学意义(P＜0.05).两者在卵巢上皮性癌中的表达均与临床分期和淋巴结转移有关.结论:DPPⅣ蛋白和Seprase蛋白参与了卵巢上皮性癌的发生发展,可能成为卵巢上皮性癌的检测指标及基因治疗的潜在靶点.