Objective To observe the changes of levels of serum tumor necrosis factor-alpha (TNF-α) ,interleukin-6 (lL-6) and endothelin (ET) in patients with essential hypertension (EH) and impaired glucose tolerance (IGT). Methods Eighty-two patients with EH were enrolled and divided into two groups (IGT: 42 cases; NGT: 40 cases). Forty healthy normotensive (NT) persons were served as controls. The serum level of TNF-α, IL-6 and ET were measured hy enzyme-linked immunosorhent assay (ELISA). Results TNF-α , IL6 and ET were significantly increased in EH group compared to NT group. [TNF-α : (27.80 ± 4.73) μmol/L vs (23.83± 2.28) μmol/L, P ＜ 0.05; IL-6: (90.62 ± 18.09) μmol/L vs (76.76 ± 12.81) μmol/L, P < 0.05; ET:(39.46 ± 10.77) ng/mL vs (30.92 ± 4.0) ng/mL, P ＜ 0.01]. Multivariate analysis showed TNF-α, IL-6, fast plasma glucose (FPC) and 2 hours plasma glucose (2hPG) were predisposing risk factors for hypertensive patients with IGT (β = 1.247, 1.180, 0.516 and 0.140, respectively; P ＜ 0.05 for all). Conclusion The concentrations of TNF-α, IL6 and ET were increased in hypertensive patients with IGT, indicating that enhanced inflammatory reaction exist in EH patients combined with IGT.%目的:观察原发性高血压(EH)合并糖耐量异常(IGT)患者血浆肿瘤坏死因子-?琢 (tumor necrosis factor-alpha,TNF-α)和白细胞介素-6(interleukin-6,IL-6)及内皮素(ET)水平的变化.方法:入选EH患者82例,其中合并 IGT者42例,糖耐量正常(NGT)者40例;同时随机挑选血压正常健康人(NT) 40例为NT组作为对照.采用ELISA法测定血浆中TNF-α、IL-6含量.结果:EH组血浆TNF-α、IL-6、ET明显高于NT 组[TNF-α,EH组(27.80 ± 4.73)ng/mL,NT组(23.83 ± 2.28)ng/mL,P ＜ 0.05; IL-6,EH组(90.62 ± 18.09)ng/mL,NT组(76.76 ± 12.81) ng/mL,P ＜ 0.05; ET,EH组(39.46 ± 10.77) ng/mL,NT组(30.92 ± 4.0) ng/mL,P ＜ 0.01].多因素logistic回归分析,EH合并IGT与TNF-α、IL-6、FPG、2hPG 呈正相关 (β为1.247、1.180、0.516、0.140,均P ＜ 0.05).结论:EH合并IGT患者血浆TNF-α、IL-6、ET增高,提示EH合并IGT患者体内炎症反应进一步增加及ET水平进一步升高.
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