Objective To investigate the clinical significance of levels of ER, PR, VEGF, CA15-3, CA125 and CEA in the prognosis of patients with breast cancer. Methods Eighty-six cases of breast cancer were received surgical treatment, and levels of ER, PR, VEGF, CA15-3, CA125 and CEA were determined and compared with those in the control group (n = 40). The relationship between the indexes and the clinical stages relapse, metastasis and treatment efficiency were analyzed. Results ER and PR expression in 22 cases were negative, and the following-up results showed that 13 cases were PD, 9 cases were SD. VEGF positive rate was higher with the rising of the clinical stage (Ⅰ ~ Ⅳ ) in the breast cancer groups. Positive rate of lymph node metastasis was significantly higher in the metastasis group. Levels of CA15-3, CA125 and CEA were significantly higher in breast cancer groups ( Ⅲ ,Ⅳ ) than those in breast cancer groups ( Ⅰ, Ⅱ ) and the control group. The indicators of recurrent were significantly higher in the cases with relapse than those without relapse. Conclusion Combination of ER, PR, VEGF, CA15-3, CA125 and CEA expression determination may have a definite clinical significance in the prognosis of patients with breast cancer.%目的:探讨乳腺癌预后判断中ER、PR的表达情况及VEGF、CA15-3、CA125和CEA水平的临床意义.方法:86例乳腺癌患者行手术治疗,术后标记ER与PR,统计表达情况和随访情况；同时检测VEGF、CA15-3、CA125和CEA水平,并与40例正常对照组指标比较,分析其与临床分期、复发转移情况及治疗效果的关系.结果:22例ER和PR均表达阴性.随访后,“双阴性”患者进展(PD) 13例,稳定(SD)9例.乳腺癌组VEGF阳性率随临床分期(Ⅰ～Ⅳ)依次升高,淋巴结转移患者阳性率明显高于无转移者(P＜0.05).Ⅲ、Ⅳ期患者CA15-3、CA125和CEA水平显著高于Ⅰ、Ⅱ期和对照组,淋巴结转移患者明显高于无转移者(P＜0.05).复发者各项指标显著高于无复发者(P＜0.05).结论:联合检测ER、PR表达情况及VEGF、CA15-3、CA125和CEA水平有一定意义,可以指导乳腺癌诊疗工作.
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