Objective To investigate the impacts of azelnidipine and mlodipine on artery stiffness and dynamic pulse pressure in patients with essential hypertension. Methods Seventy-six hypertensive patients were enrolled into the azelnidipine group and the amlodipine group in this randomized double-blind study. Each patient was given azelnidipine (8 mg) or amlodipine (5 mg) orally everyday for 12 weeks after placebo treatment. The biochemical items, the automatic blood pressure monitor (ABPM) and the brachial ankle pulse wave velocity (baPWV) were determined before and after drug treatment, respectively. Results (1) The seat pressure, ABPM paremnents, baPWV and APP decreased in two groups after 12- week treatment, respectively. (2) No significant differences for the ABPM paremnents, baPWV and APP were shown in two groups. Conclusion Azelnidipine and amlodipine can both markedly decrease baPWV and APP in patients with essential hypertension with no significant difference.%目的:研究阿折地平与氨氯地平对轻中度高血压病患者动脉僵硬度及动态脉压差(APP)的影响.方法:随机双盲双模拟平行对照将76例高血压病患者分为阿折地平组和氨氯地平组,安慰剂期后进入12周试验期,给予阿折地平8 mg或氨氯地平5 mg,每天1次,口服,安慰剂期及试验期结束前行常规生化、动态血压监测、踝-臂脉搏波传导速度(baPWV)测定.结果:(1)与治疗前相比,两组患者坐位及动态血压参数、baPWV及APP均明显降低；(2)12周后两组患者相比,动态血压参数、APP及baPWV均无明显差异.结论:阿折地平与氨氯地平均能有效降低轻中度高血压病患者动脉僵硬度及APP,但两者疗效无明显差异.
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