缺氧诱导因子HIF-1α与HIF-2α在宫颈癌组织中的表达及相关性研究

摘要

Objective To investigate the different expression and relativity between HIF-la and HIF-2a in cervical cancer tissues. Methods The expression of HIF-la and HIF-2a in cervical cancer tissues was evaluated by immunohistochemistry method. With SPSS software do differences significant analysis and correlation analysis. Results The positive expressions of HIF-la were 57.7% 、 78.6% in carcinoma in situ and infiltrating carcinoma. The positive expressions of HIF-2a were 65.4% 、85.7% in carcinoma in situ and infiltrating carcinoma. The expression score of HIF-la and HIF-2a in cervical cancer tissues was 1.56 ± 1.60 and 4.51 ± 1.04 respectiviely. The expression of HIF-la and HIF-la in Cervical cancer was positively correlated (rs = 0.855.P ＜ 0.05). Conclusion In the occurrence of cervical cancer in the process of development and metastasis HIF-la and HIF-2α may play synergy effect.%目的:研究缺氧诱导因子-1α(hypoxia inducible factor-1 alpha,HIF-1α)与缺氧诱导因子-2α(hypoxia inducible factor-2 alpha,HIF-2α)在宫颈癌组织中的表达和相关性.方法:免疫组织化学染色方法检测宫颈癌组织中HIF-1α与HIF-2α的表达.用SPSS统计软件分析HIF-1α与HIF-2α在宫颈癌组织中的相关性.结果:原位癌组、浸润癌组HIF-1α蛋白阳性表达率分别为57.7％、78.6％;HIF-2α蛋白阳性表达率分别为65.4％、85.7％,宫颈癌组织中HIF-1α阳性表达得分为1.56±1.60,HIF-2α阳性表达得分为4.51±1.04,HIF-1α和HIF-2α蛋白的表达呈显著正相关(rs=0.855,P＜0.05).结论:宫颈原发癌、浸润癌中,HIF-1α、HIF-2α表达与宫颈癌临床病理特征有密切关系,且两者表达呈显著正相关,两者在宫颈癌的发生发展及浸润转移过程中可能起协同作用.