Objective To investigate the changes of stress response on inhalation-intravenous general anesthesia during pericystectomy for Liver hydatid cyst. Methods Thirty ASA I-II patients with liver hydatidosis for pericystectomy were studied. The blood from right jugular vein were collected for measurement of serum cortisol (Cor) concentrations and glucose (BG) levels, and MAP, HR and BIS were observed and recorded at different point-times: pre-intubation for 1 min, post-intubation for 3 min, pre-incision for 1 min, post-incision for 3 min, post-incision for 10 min, post-surgical exploration 10 min. The data of pre-intubation and pre-incision served as controls. Results The levels of Cor concentration of post-incision for 10 min were decreased than those of pre-intubation and pre-incision (P<0.05); MAP of post-incision for 10 min and post-surgical exploration for 10 min were increased than those of pre-intubation and pre-incision (P < 0.01); For HR, the data of post-surgical exploration 10 min was much quicker compared with pre-incision (P < 0.01), which is slower than that of pre-intubation(P<0.01). Conclusion Inhalation-intravenous general anesthesia may inhibit the stress response during intubation,incision and surgical exploration for liver hydatidosis pericystectomy. Hemodynamic changes during incision may reflect the trend of stress response in advance.%目的：观察临床常规静吸全麻下肝包虫外膜内完整摘除术期间气管插管、切皮、探查时应激反应的变化。方法：ASAⅠ或Ⅱ级常规静吸全麻行肝包虫外膜内完整摘除术患者30例，于诱导后气管插管前1min、插管后3min、切皮前1min、切皮后3min、切皮后10min、探查后10min（或电切分离外囊与外膜时）抽取右颈内静脉血，测定血清皮质醇（Cor）浓度和血糖（BG）含量，并记录各个时间点MAP、HR及BIS值。分别以插管前、切皮前作对照。结果：Cor浓度：切皮后10min较切皮前、插管前降低（P＜0．05）。MAP：切皮后10min、探查后10min较切皮前、插管前升高（P＜0．01）。HR：探查后10min较切皮前增快（P＜0．01）、较插管前减慢（P＜0．01）。结论：临床常规静吸全麻对肝包虫外膜内完整摘除术期间气管插管和切皮探查时的应激反应有抑制作用；术中切皮时血流动力学的变化可提前反映出应激反应的变化趋势。
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