ADAMTS5表达状态与胃癌临床病理及预后的关系

摘要

目的 探讨含I型血小板结合蛋白基序的解聚蛋白样金属蛋白酶5(ADAMTS5)在人原发胃癌组织中的表达及临床意义.方法 免疫组化检测176例胃癌组织和24例癌旁组织中ADAMTS5的表达,分析ADAMTS5表达状态与患者临床病理特征和预后的关系.结果 ADAMTS5在胃癌组织中的表达显著低于癌旁正常组织,胃癌组织中ADAMTS5的表达水平与性别、病理类型、分化程度、远处转移、TNM分期和脉管浸润相关,ADAMTS5低表达是胃癌患者不良预后的独立因素.结论 ADAMTS5在胃癌组织中低表达,且与胃癌患者临床病理特征及预后密切相关,是潜在的胃癌预后不良因子和治疗靶点.%Objective To investigate the expression status of A Disintegrin and Metalloproteinase with Thrombospondin motifs 5(ADAMTS5 )and its clinical significance in primary human gastric cancer(GC). Meth-ods ADAMTS5 protein expression in 176 GC tissues and 24 adjacent normal tissues was detected by immunohisto-chemistry(IHC),and its correlation to clinicopathological features and prognosis in patients with gastric cancer was analyzed. Results ADAMTS5 expression was lower in GC tissues compared with adjacent normal tissues. Moreover,low expression of ADAMTS5 was associated with gender,histologic type,degree of differentiation,M stage,TNM stage and vascular invasion,which was also an independent indicator for poor prognosis for GC pa-tients. Conclusions ADAMTS5 expression was lower in GC tissues,which was associated with clinicopathological features and prognosis,suggesting a novel potential prognostic indicator and therapeutic target in GC.