新生儿导管相关血流感染危险因素分析

摘要

Objective To investigate the CRBSI rate,risk factors and etiological of PICC in neonates. Methods This is a retrospective case-serials analysis of 640 in-patients of newborn babies with PICC in our Hospital from 2015 to 2016,all the cases received PICC catheter treatment,and the factors of catheter-related bloodstream infections were analyzed. Results The number of PICC catheter-related bloodstream infection was 9, CRBSI rate pet 1000 central line-days was 0.60. The risk factors for CRBSI include the usage of Carbapenem antibiotic and the invasive mechanical ventilation(P < 0.05). The ratio of fungal,Staphylococcus in CRBSI was 80.00 % and 20.00%,respectively.Conclusion Possible risk factors which cause CRBSI are the usage of Carbap-enem antibiotic and the invasive mechanical ventilation.The major pathogen was fungal.%目的 探讨新生儿经外周中心静脉置管(PICC)引起的血管内导管相关感染(CRBSI)发生率、危险因素及病原学特点.方法 回顾2015、2016年两年内收住我院新生儿病房并施行PICC的患儿640例,对CRBSI的危险因素进行分析.结果 施行PICC的640例新生儿中有9例发生CRBSI,CRBSI发生率为0.60/1000导管日(10/15087).发生CRBSI的危险因素包括使用碳青霉烯类抗菌药物、机械通气史(P<0.05).在检出的病原体中,真菌为主,占80.00%,其次为葡萄球菌,占20.00%.结论 新生儿发生CRBSI的危险因素为碳青霉烯类抗菌药物的使用和机械通气的使用,致病菌大多为真菌和葡萄球菌.