人类血小板因子Ⅳ水平与恶性疟原虫感染的关系

摘要

目的 探讨疟原虫感染与血小板因子Ⅳ(PF4)的关系,为疟疾治疗提供思路.方法 采用酶联免疫法(ELISA)检测疟疾组(122例疟疾患者)和对照组(399例正常人)的血清PF4浓度,然后对2组进行PF4均值和PF4阳性率比较.结果 疟疾组的PF4水平明显高于对照组,两组比较差异有统计学意义(P＜0.05);疟疾组中的PF4高水平组和PF4正常水平组之间的恶性疟原虫密度的未存在显著差异.结论 人类PF4水平的表达与赤道几内亚疟原虫感染有一定的关系.%Objective To investigate the relationship between Plasmodium infection and platelet factor Ⅳ(PF4) and to provide the ideas for the treatment of malaria.Methods The serum PF4 concentration was determined with the Enzyme-linked immunosorbent assay (ELISA) in the malaria group (122 cases of malaria patients)and the control group (399 cases of normal).The average value (mean) and positive rate of PF4 were compared between two groups.Results The PF4 level of malaria group was significantly higher than that in the control group and the difference between two groups was statistical significance (P ＜ 0.05).There was no significant difference in Plasmodium falciparum density between the PF4 high level group and the PF4 normal group in the malaria group.Conclusions The expression of human PF4 level has definite relationship with the plasmodium infection of Equatorial Guinea.