瞬时弹性成像技术在慢性肝病肝纤维化诊断中的应用进展

摘要

The liver fibrosis is closely related to the diagnosis and treatment of chronic liver diseases. Early diagnosis of liver fibrosis might help patients with compensated liver functions slow down to the decompensated period,and also reduce the incidence of hepatocellular carcinoma. Liver biopsy is considered as the gold standard to assess the extent of liver damage in patients with chronic liver disease,but it is invasive. Transient elastography is a relatively novel,safe,noninvasive technique to evaluate liver stiffness. It can not only monitor the progression of liver fibrosis dynamically,but also objectively evaluate the liver damage. It is now widely used in clinic. In this review,the value of transient elastography in diagnosis of liver fibrosis was discussed.%肝脏纤维化程度及进展与慢性肝脏疾病的诊断与治疗密切相关。早期诊断肝纤维化程度有助于避免代偿期患者向肝硬化失代偿期发展，也有助于降低肝细胞癌的发生率。目前，临床上评估肝纤维化程度的“金标准”仍为肝脏穿刺活检，但是由于其操作的有创性，以及穿刺后可能出现的多种并发症等多种因素的影响，限制了它在临床研究中的使用。瞬时弹性成像技术无创、安全、有利于动态监测肝纤维化进展、客观评价肝脏纤维化程度，使其在国内外得到了广泛的认同，在临床上具有良好的应用前景。