阿维A治疗18例儿童泛发性脓疱性银屑病疗效及安全性分析

摘要

目的：探讨阿维A治疗儿童泛发性脓疱性银屑病的有效性及安全性。方法回顾性分析应用阿维A治疗18例泛发性脓疱性银屑病患儿的临床资料及随访情况。结果阿维A治疗的有效率为100%，50%的患儿于用药1个月达到临床痊愈，起效时间为1～2周。不良反应以皮肤瘙痒及黏膜干燥最为常见（77.8%），其次为肝酶异常（33.3%）、血脂升高（33.3%）、甲脆性增加及甲沟炎（16.7%）、脱发（5.6%），随访期间未发现骨骼系统异常。复发原因以感染最为常见。结论阿维A治疗儿童泛发性脓疱性银屑病疗效好，安全性高，可以作为治疗儿童泛发性脓疱性银屑病的首选药物。%ObjectiveTo investigate the efifcacy, side effects and safety of oral acitretin in the treatment of childhood generalized pustular psoriasis.MethodsEighteen cases of generalized pustular psoriasis who hospitalized in the Department of dermatology of Beijing Children’s Hospital were collected. The efficacy and safety of acitretin were analyzed retrospectively.ResultsThe treatment of Acitretin was considered to be effective in all cases. Clinical cure achieved in 50% cases in the ifrst month of treatment. The most common adverse effects were itch and mucocutaneous effects that presented in 77.8% patients during treatment, followed by hepatotoxicity(33.3%), hyperlipidemia(33.3%), paronychia(16.7%) and alopecia(5.6%), no skeletal system abnormalities were found during the follow-up period. The most common predisposing factor of recurrence was infection.ConclusionAs monotherapy, Acitretin is effective and safe for pediatric generalized pustular psoriasis and can be used as the ifrst choice treatment of the disease.