银屑病与肾脏疾病风险相关性队列研究的meta分析

摘要

目的：研究银屑病与肾脏疾病之间的关系。方法通过检索 Medline、PubMed、Embase、CochraneLibrary、万方数据库、中国知网，收集银屑病患者肾脏疾病发生风险的队列研究文献。所有的统计学处理均采用 Stata12.0软件。结果6篇队列研究文献符合入选标准。将各研究调整后的效应值及其95%可信区间合并后发现，纳入的6篇队列研究文献，经异质性检验采用随机效应模型进行 meta 分析，结果显示与非银屑病患者相比，银屑病患者患肾脏疾病风险增加（OR=1.17，95%CI1.07～1.29），重度银屑病患慢性肾脏疾病的发病风险更高（OR=2.06，95%CI1.93～2.2），均具有统计学意义。结论银屑病能显著增加肾脏疾病的发病风险。%Objective To study the susceptibility of psoriasis and renal disease. Methods All kinds of cohort studies comprising the risk of renal disease between psoriasis patients and control subjects were included. Six studies met our criteria, and the qualities of these studies were evaluated using the newcastle ottawa quality assessment scale. Statistical analyses were carried out with Stata software version 12.0. Results The meta-analysis showed an increased risk of renal disease in psoriasis patients (OR=1.17, 95% CI 1.07~1.29), Severe psoriasis had higher risk (OR=2.06, 95% CI 1.93~2.2). Conclusion Psoriasis may be an independent risk factor for renal diseases, severe psoriasis had higher risk than mild psoriasis.