目的：探讨TC方案（卡铂+紫杉醇）联用乌鸡白凤丸在复发性卵巢癌治疗中的作用，为乌鸡白凤丸在该方面的临床应用提供参考。方法将2011年3月~2013年3月我院收治的复发性卵巢癌的病人96例，随机分为治疗组和对照组各48例，对照组给予TC方案进行化疗，治疗组在TC方案的基础上加服乌鸡白凤丸，将两种治疗方案的疗效、不良反应及住院费用进行对比分析。结果①疗效：治疗组总有效率72.9％，对照组总有效率为70.8％，两组差异无统计学意义（ P﹥0.05）；②不良反应：a.血液系统白细胞：对照组出现Ⅲ度、Ⅳ度共24例（均值），治疗组Ⅲ度、Ⅳ度共15例（均值），对照组发生严重毒副作用例数明显高于治疗组，两组比较χ2＝10.246，P＝0.001；血小板：两组化疗6个周期血小板毒副作用分级平均度数结果显示治疗组发生毒副作用Ⅲ度、Ⅳ度共5例（均值）；对照组出现Ⅲ度、Ⅳ度共21例（均值），对照组发生严重毒副作用例数明显高于治疗组，两组比较 P：χ2＝14.207，P＝0.000有统计学意义。b.肝、肾功能毒副作用分级平均度数比较值分别为：χ2＝5.642，P＝0.018和χ2＝5.230，P＝0.022，均有统计学意义；③人均住院总费用：对照组的人均总费用为（24453±1635）元；治疗组的人均总费用为（23418±1441）元，治疗组明显低于对照组，两组比较t＝3.6081，P＝0.0005，有统计学意义。结论TC方案联用乌鸡白凤丸在复发性卵巢癌治疗中具有增强患者对化疗药物耐受力，减少不良反应的发生或减轻不良反应发生程度，降低住院费用，认为有推广应用价值。%Objective To explore the effects of TC regimen( carboplatin + paclitaxel)combined with Wuji Baifeng Pills in treating recurrent ovarian cancer and provide reference for clinical application of Wuji Baifeng Pills in this field. Methods 96 cases of recurrent ovarian cancer patients received at our hospital from March 2011 to March 2013 were randomized into treatment group and control group,each with 48 cases. Control group were given TC regimen to receive chemotherapy and treatment group were added Wuji Baifeng Pills to TC regimen. Performed comparison analysis of curative effects,adverse effects and hospitalization expenses of the two treatment regimens. Results ①Curative effects:the total ef-fective rate of treatment group was 72. 9% and control group 70. 8% and the difference had no statistical significance( P﹥0. 05);②Adverse effects:a. blood system leukocyte:control group showed 24 cases ofⅢdegree andⅣdegree(mean val-ue)and treatment group with 15 cases of Ⅲ degree and Ⅳ degree( mean value). The cases with serious toxic and side effects in control group were significantly higher than treatment group and the comparison of the two groupsχ2 =10. 246,P=0. 001;blood platelet:after 6 periods of chemotherapy of the two groups,grading average degree results of blood platelet toxic and side effects showed that treatment group occurred 5 cases ofⅢdegree andⅣdegree( mean value)toxic and side effects;control group occurred 21 cases of Ⅲ degree and Ⅳ degree( mean value)and the cases of serious toxic and side effects in control group were significantly higher than treatment group,comparison of the two groupsχ2 =14. 207,P=0. 000 and it had statistical significance. b. Grading average degree comparison value of liver and kidney function toxic and side effects wereχ2 =5. 642,P=0. 018 and χ2 =5. 230,P=0. 022,respectively and they both had statistical significance;③Per capita hospitalization total expenses:per capita total expenses of control group were( 24 453 ± 1 635 )yuan;Per capita total expenses of treatment group were(23 418 ± 1 441)yuan and treatment group was significantly lower than control group and the comparison of the two groups showed that t=3. 608 1,P=0. 000 5,and had statistical significance. Conclusion TC regimen combined with Wuji Baifeng Pills in the treatment of recurrent ovarian cancer can strengthen patients'tolerance to chemotherapy medicine,reduce the occurrence of adverse effects or lighten the occurrence degree of adverse effect and re-duce hospitalization expenses. Therefore,it is thought to have promotion and application value.
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