SUMMARY Here we report a case of leukocyte chemotactic factor 2 ( LECT2 )-associated renal amyloi-dosis ( ALect2) in our hospital.A 68-year-old male presented with massive proteinuria, hematuria, and hypertension.The renal function was normal.Light microscopy of the renal biopsy revealed glomeruli, interstitium and arteriole with amorphous pink acellular deposits on hematoxylin and eosin stain.The de-posits were strongly stained for Congo red and presented apple green birefringence viewed with polarized light.Ultrastructural examination revealed nonbranching fibrils ( diameters ranging from 8 nm to 12 nm) distributed in glomerular mesangium, subendothelia and renal interstitium.Immunohistochemistry and immunoelectron microscopy using a polyclonal anti-LECT2 antibody showed that the amyloid deposits and the fibrils were stained positively.ALect2 presented proteinuria,with or without acute/chronic renal dys-function clinically and all compartments of the kidney were involved.
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