难治型慢性腮腺炎分泌物中厌氧菌的药敏观察

摘要

Objective:To find and confirm the effective antimicrobial agents in the treatment of intractable chronic paro-tiditis. Methods:43 patients who suffered from chronic intractable parotiditis and 10 healthy control subjects were consist-ed in this study. Secretions were collected from Stensen′s duct and sent to laboratory immediately for cultivation and iden-tification of pathogenic anaerobes. Standardized disk-agar diffusion method was used for determining susceptibility to an-tibiotics. Results:The sensitive rate of ampicillin/sulbactam which were seldom used in clinical practice was the highest in the susceptibility test, followed by gentamicin and nitrofurans. A certain degree of the drug resistance was found in commonly used penicillin and the first and second generation of cephalosporin. The most resistance was found in cefra-dine. Conclusion: This survey indicates pathogenic anaerobes in intractable chronic parotid infection show more suscepti-bility to ampicillin/sulbactam.%目的：明确难治型慢性腮腺炎导管内厌氧菌的敏感抗生素，以指导临床药物治疗。方法：收集43例经反复导管冲洗及药物治疗的慢性阻塞性腮腺炎患者，通过厌氧培养系统对43例顽固性腮腺慢性炎症患者的导管脓性分泌物及10例健康对照组进行厌氧培养，同时进行抗生素药敏试验。结果：目前临床较少应用的氨苄西林/舒巴坦敏感率最高，其次为庆大霉素、呋喃类药物；对青霉素和第1、2代头孢菌素等临床普遍应用的药物均有一定程度的耐药性，尤以头孢拉定最为明显。结论：难治性腮腺炎导管内的厌氧菌，对临床常用的抗生素均产生不同程度的耐药性，而对不常应用的抗生素敏感性较高。