长链非编码RNA及其在自身免疫性疾病发生发展中的作用

摘要

长链非编码RNA(long non-coding RNA, lncRNA)是一类长度超过200个核苷酸、不编码蛋白质的功能性RNA分子。 lncRNA通过表观遗传修饰与转录调控、转录后加工、翻译调控等多种机制，在细胞生命活动中发挥重要作用。最新研究表明，lncRNA与免疫细胞的分化和激活密切相关，进而影响类风湿性关节炎、系统性红斑狼疮等多种自身免疫性疾病的发生发展，本文就lncRNA在自身免疫性疾病中的研究进展进行综述。%Long non-coding RNA (lncRNAs) is a functional non-protein-coding class whose length is longer than 200 nucleotides. Recent studies have demonstrated that a series of patterns including epigenetic modification and protein modification,regulation of target gene expression,and transcription intervention are involved in this process. The lncRNAs play crucial role in differentiation and activation of immune cells, and its relationship with human autoimmune diseases has been given more and more attention. With the development of microarray, many of the potential function of lncRNA have been discovered gradually. This article reviews recent research advances in this aspect with an attempt to better understand the role of LncRNA in autoimmune diseases .