乙草胺对昆明小鼠肝脏病理性变化的研究

摘要

Acetochlor is widely used as herbicide at present, and is frequently detected in drinking water and food which threats human health. Therefore, by setting different concentrations of low doses of acetochlor, 90 d on mouse feeding study to determine the chronic toxicity of acetochlor.The results showed that compared with the control group, the body weight of animals in the treatment groups decreased significantly(P<0.05). The higher the concentration of acetochlor was fed, the more quickly the weight of the animal loss. Observed by microscopic examination of HE staining preparation, the increase of fat and the liver cell fibrosis at different degree appeared in the livers of animals in the treatment groups. The higher the concentration, the more the hepatic fat content, the more serious degree of liver fibrosis. Therefore, we could infer that the long-term and low-dose intake of acetochlor might cause fatty liver, cirrhosis, greatly increasing the possibility of liver cancer.%通过设定不同浓度低剂量的乙草胺，对昆明小鼠进行90 d灌胃试验，来确定乙草胺的亚慢性毒性。结果表明，与空白对照组相比，受试物组的动物体重有明显下降(P＜0.05)。浓度越高，体重下降越快。通过HE染色镜检观察，发现受试物组动物肝脏出现不同程度的脂肪粒增加、肝细胞纤维化。浓度越高，肝内脂肪含量越多,肝细胞纤维化程度越严重。从试验结果可以推断，长期低剂量的摄入乙草胺，会引起脂肪肝、肝硬化，大大增加肝脏癌变的几率。