分别从健康和患病鸡、鸭、鹅分离出302株大肠杆菌，采用微量稀释法测定菌株对12种抗菌药物的敏感性。结果表明，302株大肠杆菌除对阿米卡星和多粘菌素B较敏感，对其他抗菌药物呈现不同程度的耐药且多重耐药现象严重。鹅源大肠杆菌和鸭源大肠杆菌对氨苄西林、氯霉素和环丙沙星耐药性较高，鸡源大肠杆菌对其他抗菌药物耐药率较高。同时，患病组家禽分离的大肠杆菌对氨苄西林以外的其他11种抗菌药物的耐药率明显高于健康组大肠杆菌。结果显示，辽宁锦州地区鸡、鸭、鹅三种家禽大肠杆菌对不同抗菌药物的耐药性存在差异，三种家禽对抗菌药物的整体耐药性较强，应加强耐药性监测，为指导兽医临床合理使用抗菌药物提供指导。%To study the presence of antimicrobial resistance in chicken, duck and goose Escherichia coli in Jinzhou, Liaoning Province. A total of 302 E. coli strains, isolated from chicken, duck and goose (healthy and diseased animals), were tested for resistance to 12 antimicrobials by micro-dilution method. Results showed that besides sensitive to Amikacin and Polymyxin B, all the 302 isolates were differently resistant to the other antibiotics, and multi-drug resistance was serious. Except Ampicillin, Streptomycin and Ciprofloxacin, E. coli isolates from chicken had a higher rate of resistance to the other antibiotics. Except Ampicillin, isolates from diseased poultries were markedly more resistant than those from normal poultries for the other 11 antimicrobial agents assessed. Conclusion: Despite some differences among spices, the whole antimicrobial resistance of these three poultry E. coli is severe, it's necessary to strengthen the surveillance of antimicrobial resistance and give some direc-tions to clinical medication.
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