降钙素原在鉴别细菌性脑膜炎和病毒性脑炎的临床应用

摘要

Objective:The aim of this work was to study the clinical utility of Procalcitonin in differentiating Bacterial meningitis from Viral meningitis,we also compared PCT to C-reactive protein (CRP)and White blood count.Methods:Forty one childre with clinically suspected meningitis wenr studied.Lumbar Punctures were done for cases before starting initial antibiotic treatment.According to the result of bacterial cultres and cerebrospital fluid (CSF)cytochemical profile,we classified the children patients into two groups:The Bacterial meningitis group and The Viral meningitis group.PCT、CRPand Leukocyte count were measured individually at the time of admission and after treatment. Results :PCT levels were significantly higher in patients with bacterial miningitis compared to patients with viral meningitis (P<0.05), PCT levels in bacterial meningitis group significantly decreased after antibiotic treatment (P<0.05), Conclusion:Procalcitonin level has a better diagnostic and prognostic value in distinguish between bacterial and viral meningitis,it is also a good indicator of the eefficacy of treatment of bacterial meningitis.%　　目的：研究降钙素原(Procalcitonin,PCT)在鉴别细菌性脑膜炎和病毒性脑膜炎的临床应用,同时将PCT与外周血CRP、血常规白细胞计数、脑脊液(CSF)细胞学检查等进行比较.方法：41名中枢神经系统感染患儿在进行抗生素治疗之前进行腰穿,根据细菌培养和脑脊液细胞学检查结果,将患者分成两组：细菌性脑膜炎组和病毒性脑炎组.PCT、CRP和血常规白细胞计数在入院和治疗后分别测定.结果：细菌性脑膜炎组患儿血清PCT和脑脊液PCT浓度明显高于病毒性脑炎组(P<0.05),差异均有统计学意义,且细菌性脑膜炎组患儿外周血PCT在经过抗生素治疗后较入院时明显下降,两者比较有统计学意义(P<0.05).结论：PCT对早期鉴别儿童细菌性脑膜炎和病毒性脑炎具有重要临床价值,同时也是监测细菌性脑膜炎治疗效果的一个重要指标.