气相色谱-质谱法测定美白祛斑类化妆品中的苯酚和氢醌

摘要

目的 建立测定美白祛斑类化妆品中苯酚和氢醌的气相色谱-质谱方法.方法 样品经甲醇超声提取,离心,微孔滤膜过滤,采用气相色谱-质谱法法测定.结果 苯酚和氢醌在10～200μg·mL-1浓度范围内线性良好(r=0.9999),检出限为氢醌0.01mg·kg-1、苯酚0.03mg·kg-1,平均回收率为88.7％～104.6％,RSD为2.15％～4.09％.结论 本法简便快速,结果准确可靠,可用于美白祛斑类化妆品中苯酚和氢醌的测定.%Objective To establish a GC-MS method for determination of phenol and hydroquinone in whitening and freckle-removing cosmetics. Methods The samples were extracted with methanol in ultrasonic bath, centrifuged and filtered by microporous membrane, and then analyzed by GC-MS. Results The calibration curves of phenol and hydroquinone in the range of 10-200μg·m L-1(r=0.9999) showed good linear relationships, and the average recoveries were 88.7％-104.6％ with relative standard deviations of 2.15％-4.09％.Conclusion The GC-MS method is simple and rapid, and the result is accurate and reliable.