胸腺五肽对复发性外阴阴道念珠菌病患者IL-12p70和IL-23p19水平的影响及疗效分析

摘要

Objective To observe therapeutic effect of thymopentin on IL - 12p70 and IL -23pl9 level and in patients with recurrent vulvovaginal candidiasis. Methods 80 subjects were divided into three groups, namely treatment group, control group and healthy group.IL - 12p70 and IL -23pl9 level in normal peopleand the patients of recurrent vulvovaginal candidiasis were detected by enzyme - linked immunosorbent assay -Double - antibody sandwich method before and after treatment. Results IL - 12p70 and IL -23pl9 levels in pretherapeutic patients with recurrent vulvovaginal candidiasis were significantly lower than those of healthy group, the two groups of patients had the similar level of IL - 12p70 and IL - 23pl9 ( P > 0. 05). After treat-ment, the level of IL - 12p70 and IL -23pl9 in group with thymopentin increased significantly compared with control group(P <0. 01). The therapeutic effect of treatment group(total effective rate; 80. 00% ) was signifi-cantly higher than that of control group (total effective rate: 43. 33 % ) ( P < 0. 05). Conclusion There exists imbalance of Thl/Th2 cell factors in the patients with recurrent vulvovaginal candidiasis. Thymopentin can improve the patients 'immunologic function and enhance the therapeutic effect by rectify the imbalance of the two type of cell factors.%目的 研究观察胸腺五肽对复发性外阴阴道念珠菌病患者阴道分泌物IL-12p70和IL-23p19水平的影响及疗效.方法 采用酶联免疫吸附实验(ELISA)双抗体夹心法检测复发性外阴阴道念珠菌病患者治疗组、对照组治疗前后及正常人阴道分泌物IL-12p70和IL-23p19水平.结果 两组治疗前复发性外阴阴道念珠菌病患者IL-12p70和IL-23p19水平均低于正常人(P＜0.01),两组患者间IL-12p70和IL-23p19水平相近(P＞0.05).治疗后胸腺五肽组IL-12p70和IL-23p19水平升高,对照组治疗前后水平差异无统计学意义(P＞0.05).治疗组的疗效(总有效率80.00％)明显高于对照组的43.33％ (P ＜0.05).结论 复发性外阴阴道念珠菌病患者存在着Th1/Th2型细胞因子失衡,胸腺五肽可通过纠正两型细胞因子失衡而改善患者免疫功能,提高治疗效果.