p53基因第72位密码子多态性与HPV相关食管鳞癌遗传易感性的研究

摘要

目的 探究p53 基因第72位密码子(codon72)多态性与HPV相关食管鳞癌的关联性.方法 选择435例食管鳞癌(Esophageal Squamous Cell Carcinoma,ESCC)患者和550例健康对照,进行p53 codon72与食管鳞癌发生的关联研究.结果 病例组的Arg/Arg基因型的频率高于对照组(85.7% vs 49.6%);Arg/Arg基因型携带者发生食管鳞癌的风险是携带Arg/Pro或Pro/Pro基因型个体的6.48倍(P<0.001).结论 p53 codon72纯合子Arg/Arg可能是HPV相关食管鳞癌发生的危险因素.%Objective To address a potential correlation between the genotypes of p53 codon 72 and the risk of HPV related esophageal squamous cell carcinoma ( ESCC ) . Methods p53 codon 72 polymorphism in 435 patients with ESCC and 550 cancer - free subjects from the same geographical region were investigated. Results p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects (85.7% vs 49.6% ,P<0.001),resulting in an elevated ESCC risk (OR = 6. 48,95% , CI = 4.65-9.03). Conclusion p53 Arg represents a potential risk for the development of HPV related ESCC.